Unfortunately, that diagram doesn't help, because it doesn't identify the individual pins in the front panel i/o connector. With the Dell "all in one" socket, there is no need to know the pin assignments, because you just plug it in, and it works. With a new case, you will have individual wires coming from the front panel, for power on, reset, HDD activity LED etc. and you need to know which goes on which pin. You could probably get them all connected correctly with some trial and error.
Maybe someone else here has already figured out the pin assignments, or there is some technical sheets available (I didn't scroll through the entire manual you linked to, perhaps it does show the pin assignments in detail).
Edit: I just saw your edit. How many pins are in connection 22 on the motherboard?