Yes, there are plenty of high end cases on the market that will suite your needs. The Phanteks Enthoo Luxe will support a H115i on top and will not come close to RAM clearance issues. I know this because I have that case in another system. It is a very nice case, but just a little bigger than the Define R6. I don't know what features you are looking for in a case, but I am certain that the Enthoo Luxe has everyone of those features. You can even run a push/pull configuration with a 280mm rad on top of the case. The build in your pcpartpicker list will support the Enthoo Luxe very easily.
The Define R6 is a very good case as well (quieter than the Enthoo Luxe) and typically the issues with radiator clearances deals with the heat sink on the mobo as Karadjgne said earlier. This is what the guy in the video stated that the mobo he used had large heat sinks and that most people who will buy this case will probably have high end motherboards because the case is not cheap.
Additionally, the age old question of front mounted radiators. I live in Houston Texas and even in mid October, it was 95F over the weekend. So I understand living in a hot spot in the world. My 280mm radiator is in the front of the case. That really should not impact your consideration. There are advantages of having the radiator in the front and disadvantages. With your rad in the front you will have cooler CPU temps than if it was on top. But by cooler, by maybe a degree or two.
The problem is that the cool air comes in from and it is heated as it passes through the rad cooling the CPU. That hot air is used to cool the GPU, which hot air cooling a GPU wont cool it as well. Again, we are talking about a degree or two difference. If you move the rad to the top of the case, the GPU will use the cool air from the front intake of the case, and expel that hot air right below the CPU. Since hot air rises, that hot air will go through your CPU radiator and will be used to cool your CPU. Therefore, hot air cooling a CPU wont cool it as well as cool air and you will see a couple of degrees difference.
In the end, you are worried about a few of degrees difference. A few degrees will not have any impact on performance. Unless you are a professional overclocker trying to break world records, you will never no the difference. Even if you were a pro overclocker, you would not use the Define R6.
Lastly, if performance and cooling is your primary goal, then don't go with the Define R6. It is a fantastic case, but it is designed more for sound dampening than cooling. I have a 1950x and a 1080ti in my Define R6 and it is much quieter than my 8700k and 1080ti in the Enthoo Luxe. But the Enthoo Luxe is several degrees cooler. So there is always a trade off. It sounds like you are more worried about heat than sound, so I would go with the Enthoo Luxe.