It's not listed in the compatibility list (http://dlcdnet.asus.com/pub/ASUS/mb/SocketAM4/PRIME_B350-PLUS/PRIME-B350-PLUS_Memory_QVL_180126.pdf?_ga=2.120062476.586212630.1523701629-470164751.1523701629): that means that it may not get to 3000MHz, and you may have to run it at slightly lower speeds, maybe 2933MHz or 2800MHz. It won't make a huge difference performance wise, so i would go for it. Hope it helps!