No, but you can use a SATA drive in the place of the cd drive.
NVME requires a PCIe lane for it to work, SATA uses different protocols and voltages.
m.2 will support SATA and NVME, but a SATA port cannot support an NVME drive at all.
https://www.amazon.com/second-hdd-caddy/s?page=1&rh=i%3Aaps%2Ck%3Asecond%20hdd%20caddy
you will need something like one of these. get the proper height as there are three. 7, 9, and 12mm.
not an endorsement, example only shop around
a standard SATA SSD will go where the HDD is and the HDD will go in to this. the CD's SATA port MAY be slower so I suggest putting the HDD in the caddy/tray.
unless you have 2 NVME drives that need large files transferred back and forth a SATA drive will be fast enough, you will need bench marking software to measure the differences in daily operation