Looking at the detailed specifications, you might be able to do that BUT it would hurt your performance. The one M.2 slot is a PCIe 2.0 x4. That will lower the performance of your faster PCIe 3.0 M.2 slot. A single M.2 is a much better answer. 250GB for C: is sufficient to prevent accidentally filling it. If you must, setup the second M.2 as D: ...