nope
My motherboard doesnt have any RGB lights but I can still control the rgb lighting on the ROG Strix gpu
It says on Asus website:
"For Users Without ASUS Aura-Sync Motherboard
Users can navigate to the VGA support page. Find the correct model, and download the AURA Sync application under Drivers & Tools tab, under Utilities"
https://www.asus.com/support/FAQ/1035210/