If you have some experience with the combination of the above two parts, would you recommend to overclock the CPU to 4.5Ghz at least?
The goal is 5.0Ghz.
It should be able to handle 4.5, i would recommend getting a better thermal paste like arctic silver 5 or thermal Grizzly kryounaut. You might get to 5 GHz but I might recommend a better cooler for that.