Why would you want to Disable ULPS? If you have two AMD card's in crossfire, it probably has ULPS enabled. ULPS disables the second GPU when not in use. This is alright but sometimes it causes issues in overclocking and/or playing certain games. It can also cause other problems do for troubleshooting purposes, it is recommended to disable ULPS.
Go to the registry by typing "regedit" in windows search.
Go to the "Edit" tab and click on "Find".
In the text box type in "EnableULPS" and then press Find.
You should see "EnableULPS". Double click on it.
Change the value from "1" to "0"
ULPS should now be disabled. Although you can opt to disable it in Afterburner and Catalyst Control Center, it often gets turned back on after an update and so doing this is more efficient.
Note: If you want to turn ULPS back on, simply change the value back to "1".
Thanks for Reading