Disabling multiple GPU was a quick fix for me. It's just probably because all these MMORPG's are built with older engines and they can't support the newest VGA cards.
I think the Graphic cards are way ahead of the developers technology...
Defenitly, which is why im going with a more mid range system now then a high end system, im pretty much waiting till after summer so i can upgrade my pc with a bigger budget. Like i said, lots of these older games dont like the newer GPUs or SLI/CF