Running fine here, all graphics set to maximum and running at 1920x1200 at CONSTANT 62FPS (even with vsync off, never wavers). No AA as that needs to be enabled through Catalyst and I'll never remember to turn that on before or application controlled afterwards!
Q6600 @ 3.4
2 x 4870 1GB
Very beautiful game, and I personally find combat satisfying as even mashing just the left mouse button still produces a nice looking array of moves. Add in a few right and middle clicks and you feel like a god.