8800GT's in SLi on a 680i with an e8400 @ 1920 x 1080, but SLi seems to be broken and because I can't get the latest beta drivers to run on the Vista partition I can't confirm whether physx works or not, but that said it runs really smoothly if you like that sort of thing.
As I said SLi seems to be broken but one 8800GT gets 40 - 45FPS @ 19 x 10 with 4 AA, I just get fed up punching and kicking sometimes you gotta shoot a baddie in the face to get proper stress relief.
And that's why Fallout 3 does it for me: when I'm angry at something / someone / stupid customers, I break out the combat shotgun and go shoot some Super Mutants in the face and blow their heads off. Then I get all giddy inside, and then back to normal.
Running fine here, all graphics set to maximum and running at 1920x1200 at CONSTANT 62FPS (even with vsync off, never wavers). No AA as that needs to be enabled through Catalyst and I'll never remember to turn that on before or application controlled afterwards!
Q6600 @ 3.4
2 x 4870 1GB
Very beautiful game, and I personally find combat satisfying as even mashing just the left mouse button still produces a nice looking array of moves. Add in a few right and middle clicks and you feel like a god.