What is the best API for programming GUI applications in Unix and Mac

I've heard of GTK+, Cocoa API and others, but which API do you recommend to learn to program applications for Mac, and other Unix/Linux systems like Redhat and SuSE?
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More about what programming applications unix
  1. Mac - Cocoa (you'll need to learn Objective-C).
    Linux - GTK or QT (you'll need to learn C and C++).
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