Mass effect 2 not responding in the first loading screen

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Hello,my mass effect 2 is not responding in the first loading screen...as soon as selest the genser for playin it gos to a loaing screen which looks like loading but i have go to task manager in order to close it...i have a core 2 duo 2.8 ghz...4 gb ram...ati radeon 4670...vista 32...and all the latest directx and drivers....please help