do you have to erase the hardrive when changing motherboards?
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You have to reinstall the OS, and re-formatting the disk is an option during installation (and I highly recommend doing this). Keep in mind, though, that everything on the disk will be gone (documents, programs, etc) so back up your data first.
Actually you don't with W7, all you will neeed to do is install the drivers for the new motherboard and reactivate Windows (you have 3 days). My mb died and I replaced mb with different make new cpu and ram and my pc booted fine, I installed the mb drivers and phoned Microsoft to reactivate. Smmoth as.