What mouse. Which keyboard?
Have you tried the PS2 port with USB to PS2 adapter?
The first one is just a power wave (cheapo) usb mouse. The second mouse i tried was a logitech g9. The keyboard is a zboard. The g9 mouse works on my laptop which runs vista, old pc which was xp, so I don't know if it is, but seems to point to win 7? I am using a mouse in the ps2 port, but I do not have a usb to ps2 adapter to try the usb mouse in that port. But the mouse is working for sure.