you av is probably the problem. its likley its blocking the disks copy protection. to get round it.
go to start/run
and type msconfig
select selective startup and uncheck everything you can
click apply and select reboot.
you should now reboot in what amounts to safe mode with no anti virus running. insert your game and run it. it should now see the disk and boot properly.
there are a couple of solutions that may help, update your anti virus to the latest version. or patch the game after install. either 1 of these may fix the problem.
don't forget to reset your boot config 1s your done playing
start/run
msconfig
select normal startup
click apply/ok
reboot.
if you want, disable the INTERNET while you play(or at the least make sure your firewall is running).