Yea the Creation engine looks absolutely spectacular. Todd Howard (lead production designer) has gone so far as to say no two playthroughs will be the same. I know we've heard that before, but this time, a little optemistic part of me thinks it may just work. Completionists will get a LOT of value of out Skyrim
@Bob: totally agree. I know there's Mages Guild, Fighters Guild and Dark Brotherhood confirmed, and Thieve's Guild was just far too good a premise to miss out on, so I'm pretty certain that'll remain as well.
I hope they make the enchanting/spellmaking a bit more interesting. I found the constant recharges needed for enchanted weapons very frustrating as they ran down far too quickly. Also the whole spellmaking thing was really just the opportunity to play with spell values rather than actually *create* any spells - hope they address this so that you can combine and create potentially limitless spells.
Anyhow, it looks absolutely epic from my point of view, and I'm literally counting down the days
-Nih