Wow..... too many drive letters. If you have multiple hard drives, set up one partition on each and structure them as follows...
C: OS, Swap and Temp files - Despite what many people think, moving the swap file to another partition slows the drive down considerably due to the write heads having to move back and forth between the different partitions depending on how far apart the partitions are physically located from each other on the disk. To a degree, this is also true for a swap file on the same partition, but it doesn't affect performance nearly as much. Leave the swap file on the same partition. If your computer has a lot of RAM (8GB or more), you can get away with setting a small swap file size, say around 512MB, or possibly do without one at all. I tend to recommend that people avoid not using a swap file though, as some programs do actually require that one be present.
D: All installed Apps and Games - Do this especially if you can set up a RAID 0 array for Games or other disposable data. Disposable data being things you can get back or rebuild one way or another, through reinstalling the application or some other method depending on the program in question.
E: Backups - Keep all of your program installers and setup files here in case something happens to either of the other drives and/or RAID arrays. Another backup of this drive kept either offline (i.e. Not constantly hooked up to the computer and running), or off-site (another physical location) is also preferable, but if you can't afford this many drives, the drive serving as the backup of the backup can be omitted.
This is the setup I use on my main desktop. My instance of Windows 7 has fudged itself once (not really fudged itself, the Media Center guide simply wouldn't download no matter what I did. This was important to me since I record a lot of shows via Media Center), and I was able to get my system running exactly as it was before - minus the Media Center issue - within 4-5 hours. All device drivers, all applications, exactly as they were before.