I'm running two Radeon 6950s in crossfire. Skyrim's graphic auto-detection was at High so i left it there. During the beginning i didn't notice any problems. Even after leaving the cave area it seemed ok for a little while. Then after exploring for another 30 minutes or so I started seeing flickering of some textures (only some) in the environment. Rebooting didnt help. Even in the startup screen I now see flickering - its weird. Doesn't seem to be a cooling issue as MSI afterburner shows my temps below 60c. Also - nothing is overclocked. Any help or advice with settings would be greatly appreciated!!!
I seem to recall reading that Crossfire wasn't [yet] supported for Skyrim. I'd start by turning that off.