hey hey i have exactly the same problem, even the same crash message, but i never changed my gpu.
what do you mean with application profile? the application profile of your graphic drivers or is this something from steam?
i also could play it any time, then i stopped playing it for a month I think and have had these pixel problems, so i deleted all my mods, because I thought it comes from their and did a clean reinstall (deleted skyrim.ini, cleared mod and instalation folder, regestry clean). Nothing worked, then I heard it is because of 12.3 catalyst and installed 12.1.
Since here skyrim doesn't start anymore, like in goombaxiv's case, exact the same crash message. I also tried it with the lower the sound to cd or dvd quality nothing worked.
so what exactly do you mean with application profile?