1) First of all, go to the following folder. It's a hidden folder, so you might need to enable 'show hidden files' option, or manually enter the path in the explorer address bar:
C:\Documents and Settings\<username>\Local Settings\Application Data\capcom\DEVILMAYCRY4
2) There should be a file named "config.ini", open it with notepad.
3) Locate the line "SLI=ON". Change this to "SLI=OFF". This is the FIX.
4) Save the file, and you're done.
this may fix the load crash that you may be getting as it seems its crashing b4 the level 5 cutscene.