I know I'm a little late to the party here, but I just started playing Borderlands 2 in earnest and have noticed severe framerate hitches. They were severe when I was playing the game at high and even medium PhysX settings, so I turned PhysX to low (leaving everything else maxed) but some drops still persisted. Predictably, these drops come in larger areas with a higher concentration of enemies. My drivers are all updated to the latest version.
GTX 680 2gb
i7 3770k @ 3.5
P8 z77 V-LK mobo
16 GB ram
256 GB SSD
Any help would be greatly appreciated, thanks.
"Predictably, these drops come in larger areas with a higher concentration of enemies". You said it yourself, more Visuals Means worse performance.
What resolution are you playing at?