First off, make sure your BIOS and drivers are up to date. Here's the link to do so: http://www.asus.com/Motherboards/Intel_Socket_1366/P6X58DE/#download
Secondly, is is your whole computer that freezes, or merely your games. If it's just the game, then it's most likely software related. If it's your whole computer, it MIGHT be hardware related. Check to see that there aren't any loose wires or not-quite-seated parts.