Hey Envy,
I have 2 different hdd's with my Asus A8N32-SLI, one is a WEstern Dig RAptor SATA 74.3 gig 10 K and the other is 2 Maxtor SATA II 250 gig 16mb cache hdds. I have not had any problems with either of them. I have XP and apps running off my Raptor and my games, MP3's, and movies are on 1 of the other Maxtors. The third drive is unplugged and used for backing up "MY Documents" and only used for that purpose. That way if I get a virus, all I have to do is wipe my other drives and reinstall.
But as you can see I have both drives different and they work well together. It's not uncommon to see that in gaming rigs.
System specs;
Antec P180 PerformanceSeries mid-Tower
Asus A8N32 SLI mobo (bios version 1103 V02.58)
AMD Athlon 64 X2 4800+ Toledo Core, 2 X 1mb L2 cache (amd drivers w/MS hotfix)
2 gigs of Corsair TwinX3500LL Pro @ 437Mhz 2-3-2-6-1T
2- BFG 7900 GT OC 256mg in SLI (nvidia driver version 84.21)
Western Digital RAPTOR 74.3 gig 10-K rpm HDD for XP & apps
Maxtor SATA II 250 G HDD for gaming, movies, MP3's
Maxtor SATA II 250 G HDD for document backup (unplugged)
52 X sony cd rom
Plextor 708A DVD/cd rom
SeaSonic S12 600 watt power supply
Logitech Z 5500 digital 5.1 THX Surround 500watts
RealTek 97 onboard digital sound
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