For Artic Silver 5 as it's says in the website it usually takes around 2 weeks of 8 hour daily operation to make the thermal compound set and performs at best. What's happening is through heating up and cooling down with normal use, the molecules or mixtures settles and somewhat arrange itself thus enabling to transfer heat in it's optimum performance. So always replace thermal compounds every time you break the connection or removing the cpu, gpu , n/b coolers and etc.