Bro wer need more info that that. What do you plan on doing with this machine? How many HD's, what video card , how much of what kind of memory?
If you want suggestions
Go with the new Core 2 Duo E6400
The Gigabye DS mobo
just grab a mid grade vid card for now, like 7600GT or the ATI X800 till the DX10 cards come out
For mem id get the Cas5 2x 1gb Corsair XMS.