Well, not really a professional review but can share my recent Crosshair experience (new poster to the forumz). I was actually trying to wait for a Conroe 590 board to come out and get a C2D, but needed to act now and decided to give Crosshair a try:
Asus Crosshair
X2 4600+
2GB Corsair 6400C4
Zalman 9500 AM2 Cooler
Arctic Silver 5
Silverstone Zeus ST65ZF 650W PS
BFG 7900 GTX OC
Seagate 320 GB SATA HD
Gigabyte Aurora3D case
LiteOn DVD writer
Win XP Pro
Board was easy to install, good layout everything fit nicely, good cable routing possibilities. The Zalman cooler fits in fine, no clearance problems with the heatsinks, good airflow through case. Currently idle temp 33deg, low 40's under heavy load (using stock speeds).
Onboard switches nice addition when working on an open case. Lights on the I/O shield a really nice touch for less than perfect lighting. The 3 extra thermo cables allow for monitoring of other components (video card, HDD, etc.), as CPU and NB have own integrated temp sensors. With a second 2-slot video card in there, will be tight but will still have a PCI slot between sound card and first PCIx16 slot. Could also possible have a PCI slot between the two cards, but a tight squeeze.
Board POSTed into BIOS fine on first powerup, menus easy to navigate. Needed to make a minor change to recognize correct 4-4-4-12 timings on Corsair sticks in subsequent restarts, now all good. Booted through and installed Windows to completion also on first power-up. Knock on wood - everything seems to be working fine so far. Running straight for a week now. Sounds seems great for gaming and music, have noticed no discernable difference compared to my older Audigy.
ASUS included software OK. PCProbeII allows you to keep an eye on just about everything in the case (voltages, temps, fan RPM). Complete Advnced Edition of 3DMark06 cool to have.
Just starting to explore OC'ing..... More options than I know what to do with, so this should be fun ! Considering what I have seen so far and the potential of this board justifies the price compared to what else is out there. This or an M2NE Deluxe, hard for me to say since I've never used the latter.
Hope this helps!