full screen, seems no matter if I set my A filtering at 4 and my Antialising at 16x there is not much of a difference in picture quality
That's right. AA and AF have no effect on overlays and avis, movs and mpgs are overlays.
Of course I realize the internet connecion speed and video quality being piped out to me are major factors too.
Internet connection has nothing to do with IQ. Internet connection can only impact your frame rate. Thing is that streaming videos en mass are low resolution and when you blow them up you get all the blocking and ringing. It is a mess. Cannot be avoided.
But, what can I do if anything to clear up the picture. Sometimes in full screen the picture is really poor quality.
Do not use full screen.
When I said "use overlays" in my original response I meant that by controling overlay settings in the driver control panel you can adjust saturation, gamma, sharpness, digital vibrance and things like that. This helps somewhat because if the saturation is too high you can see all the color distortions of pixelated image. Remember low quality JPEGs when blown up? This is what you are getting when blowing up low res videos. (Each frame is a still image of great compression and low resolution). Reduce saturation and suddenly the image looks more natural and clean.