Reinstalled Windows 7 now a program won't open

I just reinstalled Windows 7 Home Premium because I had about 4 redirecting issues or viruses when I would use any search engine. Anyway. Now I can't run a program that ran perfectly before. I uninstalled and reinstalled. I used the compatibility trouble shooter. The only thing I haven't done is get all my drivers yet. Could not having all my drivers make a program unresponsive or do you think it is a separate problem. Like I said it worked perfect before and the only difference is I had all my drivers installed.
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  1. WHAT is the software you are trying to run?
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