The 4x PCI-E should not be a problem as the PCI-E standard allows for this.
There are reviews on anantech where they test the PCI-E Vs AGP VS fuller PCI-E, and there is little performance drop, also DDR against DDR2.
I'm happy with mine, my PCI-E bandwidth might be getting saturated with my 7900GTO, but not very often, and I get very good FPS at very good settings.