I too have the P5B Deluxe/ WiFii and have had it a couple months now and have found it to be an excellent board.
I did have the problems with the onboard sound, but did not put much effort into correcting it since I had already planned to use my own sound card.
Overclocking is quite easy and very stable at resonable levels, assuming you use quality memory (be sure to check and use the memory compatability list)
> Memory compatability List <
You mentioned gaming If you plan to use 2 cards in SLI. I'd look at another model, or go with a single Geforce 8800 series card and you'll be ready for Vista and DX10
ASUS P5B Deluxe/WiFi-AP Motherboard
Intel Core 2 Duo E6400 Conroe 2.13GHz Processor fsb 1066MHz
Overclocked and running at 2.560 FSB @1280MHz w/ stock CPU cooling (for now)
Thermaltake Xaser Case w/ 5-Variable speed 80mm LED fans
Enermax Front Panel with LCD temp readout and fan speed controls
ATI All-In-Wonder Radeon X1900 256MB GDDR3 PCI-E x16 Video Card (used as DVR, HTPC)
CORSAIR XMS2 2GB (2 x 1GB) DDR2 SDRAM DDR2 800 (PC2 6400)
SCEPTRE X20G-Naga III Black 20.1" 8ms Widescreen HD Ready LCD Monitor
SeaSonic S12-600 ATX12V 600W Power Supply
2 x 200GB SATA Western Digital Hardrives
Sound Blaster Audigy
Backup -1 External 80GB (USB2) Hard Drive, 1 60GB IDE Drives, 1 30GB Drive (ide/usb adapter)
NEC DVD Burner