x86 processors are not 64 bit. They are 32 bit processors with 64 bit extended instruction sets, to allow larger memory usage, and to add some 64 bit data instructions.
True 64 bit processors, like the IBM power pc, the Sun sparc's, are generally RISC (reduced instruction set CPU's) processors that will natively handle memory out to 64 bits (2 to the 64th), and will handle computational processing faster overall. Large databases need these processors, as does high end graphics procesing.
As to what your really asking, (since I doubt you are talking about a power pc WS) MPJesse has it right at least for now. Vista 64 is not for the faint of heart. If XP is anything to judge by, it will never be.
Kinda makes one wonder why Apple dropped the power pc chip for the mac.
I have a Sun WS at work that will run say Solaris 10 at twice the speed of this pc despite having one fourth the RAM and one third the processor speed...