I've just looked into the matter and notice that registered/buffered RAM communicates differently from non-registered/unbuffered RAM, making it unlikely for one to run server DIMMs on a desktop board. While the traces are the same, on the K8 platform, the incompatibility arises from the IMC being unable to communicate with registered modules, but we know that multisocket Opterons don't have that problem.
However, most motherboards using non-registered RAM either support ECC or can accept ECC RAM (merely running it without ECC capability). Actual use of ECC requires ECC modules, ECC BIOS support, and an ECC memory controller, but to run an ECC module in non-ECC mode is pretty trivial.
My response to the OP remains fundamentally unchanged, though, in that without BIOS support, a 2S Opteron board cannot even power up an FX-7x series processor, as it wouldn't know the proper voltage to apply. Additionally, unbuffered memory support may not be common to all Opterons - I recently heard about Opterons running on QFX, but they were very advanced steppings that might not even be available to retail yet.