Should be no problem. I have the DQ6. I have 2 paires of HDD on the Intel Sata ports, A SATA plextor 755SA and I just installed a Samsung Sata 183L - both on the JMicron Sata ports. I'm using the only IDE port for a removable IDE HDD.
E6400 clocked to 3.2 GHz
2 Gigs of Corsair DDR2 6400 1::1 with 400 Mz Bus
AIW 2006 Graphics card - not a Gamer.