Don't see why not. The only thing you really need to consider is the height and weight of a new CPU cooler. The heavier, the more stress on the mobo.
If you go to a lot of LAN parties, might want to search for a light weight, yet efficient CPU cooler.
Also, make sure you have very adequate air flow within your case. Normally a fan on the front pulling in fresh air and a fan in the back located near the CPU to exhaust the hot air