well, vista does take up 10GBs by itself, if you have vista, dont go for a 36GB, XP though only takes up about 1.5GB for a full install... ...but, if somebody (not saying you in particular) needs that many hundred gigabytes for an OS hdd, they most likely either have way too much junk and dont do regular maintainance on their hdd... or theyre not storing their other media on other more appropriate hdds/locations, which would result in poorer OS hdd performance as a whole, not to mention possibly taking that much longer to defrag, unless they have multiple partitions, whichcase, not quite so long to defrag
but, for simply an OS and a few games (even at 4GBs a piece), and other applications, 150GB is easily more than enough
but for general storage, you may need multi terabytes worth
take for instance my setup, i have vista rtm and all my applications and games on a 74GB ADFD raptor (still only halfway filled), a 2.3GB pagefile on a 400GB storage hdd, and my internet cache on a small partition on yet another hdd (300MB partition on a 36GB GD raptor)... and then just other hdds for storage/data redundancy as well