I use System Suite 6 Pro, it has a boatload of utilities including a registry fixer, which I have never had a problem with, I think I started with vesion 4 or 5 but have been using System Suite for years. It has a Defrag component that wiped out a SATA drive so I just use the Windows defrag, otherwise never had a problem. I think the their Fix It program has the same Registry Fixer program and is about $10 or so cheaper. You can always find it on sale with rebates somewhere. Worth checking out.
i also tried Registry Fix & Reg Cure..they both works f9 but it only cleans regs , i think optimization also required ...i tried lots of software..i can suggest Regclean Pro provided by Systweak..It cleans and optimize registries..which are affecting badly..to ur PC..its a best registry cleaner i used so far..!Its compatible with 64 bit Windows Vista & Win 7.
it helped me a lot..!! U can download it 4m systweak site..!