I use to be a regular user of Mcafee up to version 7.0, but then they changed the interface and ruined it. When I bought my laptop it came with a 1 year license of Mcafee Internet security 2006, but I uninstalled it because it was awful. I found it to be too computer resource hungry just like its main rival Norton. The problem with Mcafee is if one only uses one of their products like the Anti-virus for example one still has to have the sercurity centre installed. The sercurity centre likes to spring up advertising pop-ups trying to get someone to buy their other products. It never scores that well in tests because it's detection is nothing to shout about.
I have only started using Kaspersky Anti-virus and I like it. First off it feels light on my system resource and the interface is simple to use. Updates are regular too. Tests show Kaspersky to usually lead in detection along with Nod32.
Mcafee or Kasperky = Kaspersky wins by a mile