Sometimes when I play a game afterwards all of my windows (browser windows etc.) open and close really slowly and the problem doesn't go away until I restart my computer. It happens regardless if I have an OC or not. I'm on a amd 4400+, x1950gt, and 2 gigs ddr400 ram.
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Start - Run - MSCONFIG, Startup tab. Untick all boxes and see if it solves your problem. If it does, re-enable a few at a time and identify the culprit. Also check for virus or Spyware.