Look into disabling all the remote access stuff and unnecessary services too
inetd, nfs, ssh, vnc, wireless and so on should be disabled if you don't need them.
If you do need them, you'll want to block access from all IPs except your own.
If you decide to give WINE a try you should be extra careful because WINE can allow windows viruses to run on Linux. Without WINE or something similar Linux is 100% immune to windows viruses.
Good luck and keep the questions coming