I would say 25XP/40Vista/rest for storage. If you're building a system, and depending on the age of your 250, why not upgrade the primary drive to a larger capacity/higher performance from the get-go... Say 640GB and use the 250 for storage and backup?
Its a brand new Seagate Sata II 7200.10 for my primary.
I'm not a big fan of hard drives any larger than about 250 gigs.
If something happens to a hard drive I don't want to lose 500 gigs worth of stuff.
I have a few older and slower hard drives to also act as storage for things I won't use much.
I'll just buy another one as I need it. Plus I would really like one of these WD Velociraptors down the road (when they are sub $200). 3.0gb/s 10,000rpm NICE
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