Unlocking User Profile Folder

[MiSmitty]

I am trying to help a friend with her computer. The OS is XP home and a user profile folder is locked. The user is no longer with us and it is using over half the hard drive space.
My question is; how can I unlock this folder and remove the files?

 

[Guest]

Boot into Safe mode and then http://support.microsoft.com/kb/810881/en-us

Grumpy