Unlocking User Profile Folder

I am trying to help a friend with her computer. The OS is XP home and a user profile folder is locked. The user is no longer with us and it is using over half the hard drive space.
My question is; how can I unlock this folder and remove the files?
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More about unlocking user profile folder
  1. Boot into Safe mode and then http://support.microsoft.com/kb/810881/en-us

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Computers Windows XP