Logitech cams work with Vista 64... I have the Quickcam Orbit MP. The older ones likely won't, but all the newer ones should. MS webcams should also work. Cheap, no-name cams are a pain in the ass to find drivers for... even 32-bit ones. I know they are more expensive, but you are better off with a big brand-name cam. Logitech, MS or Creative.