Winlogon keeps popping on startup, need help immediately

I received a message from a friend yesterday thru MSN messenger, he sent me a screensaver link and I thought it was a screensaver he made from the pictures we took. After I downloaded the file and clicked on it, nothing happened. So today I turned on my computer, and a Winlogon properties keeps popping on my desktop. I have to click the close button for several times until it disappears.

I checked on some malware pages, and noticed that this is some kind of virus that could hack into emails and files. Do anyone know what I can do before the winlogon turns into something that can cause problems to my comp.

Spec: Windows Vista Home Premium 64-bit
This is the image of the winlogon on the startup:


The file I downloaded yesterday is DSC00148.SCR

for some reason, it wouldn't let me run any command key, I've tried msconfig, cmd on the run. But it pops a window with search "No items match your search". The run command used to work before, but somehow it isn't working properly now. Any idea of what causes this..?

Edit: Cmd is still not working, but it is on the search results and can be opened now.. but not msconfig.