I wasen't sure where to post this due to me not knowing what exactly is causing the issue. I've recently been having problems with my mouse in certain games if not all of them, though the problem is not the same with every game.
Team Fortress 2 - Mouse will spin out of control randomly
Left 4 Dead - Mouse is jumpy and not smooth at all times
Battlefield Heroes - When left clicking mouse sensitivity will drop to a point where it becomes impossible to turn almost
Dawn of War 2 - No noticeable problems
Warcraft 3: Frozen Throne - No noticeable problems
It seems like the common issue between games would be sensitivity (maybe), but I'm not absolutely sure.
These are the games I play the most on my PC and have been noticing the problem in, the only reason I mention that I don't notice a problem in some games is because I didn't want anyone to think it was because of a certain game engine (I initially thought the issue only occurred with the source engine).
Anyways I have two mice that I tested this with using the most up to date drivers for both. The same problems occur with both mice (Saitek GM3200, Logitech G5).
System specs
OS - Windows Vista Home Premium x64
Motherboard - Asus P5K/EPU
Processor - Intel Core 2 Duo CPU E8500 3.16GHz
Video Card - ATI Radeon HD 4850
If more information is needed I can post my DxDiag