It uses a different DIMM-internal design and some modest differences in DIMM-external signalling. It's not compatible with DDR2, so you'll have to have a new MB that supports DDR3 to use it. Its speed grades will start where DDR2 is topping out, in the 800-1066MHz effective data rate area, and go higher. Since Intel CPU FSBs are the current bottleneck on memory, it's not likely to come into general use for another year or so at least.