You don't have to do anything for any type of hard drives to make sure they are not running in a RAID setup so that isn't your concern.
I'd update the BIOS and the chipset of your MB if you have not done so.
If you have, you may want to throw another hard drive in there to see if you get the same problem. If you don't have a spare hard drive, you need to run some hard drive tests against your hard drive. The vendor usually has software they use to test their hard drives.