I've got the two* systems in my flat: Main PC, File Server.
The main PC has a single fan blowing over the drives, specifically a 120mm. This is more than adequate for the two 7200RPM Western Digital 80GB drives I have in it. I don't think either drive has gone over 36ºC since I installed them, and that high was on a really hot day.
My file server mounts six hot-swap 15,000RPM 300GB SCSI disks in a RAID stripe array, and the drive bay for these six drives has two dedicated 120mm fans pulling air through it. The air that comes off those drives after a heavy thrashing session (i.e. defragging, or moving a few gigabytes of data from A to B) can get quite warm. I've never actually plonked a thermometer onto the bay, but my guess (based on touch) is that it's around 35ºC as well.
A WD Raptor probably would benefit slightly from additional cooling, seeing as how it's SCSI technology with IDE/ATA controllers, and SCSI drives with high RPM ratings can get quite warm. Since I don't run a Raptor anywhere, I really can't say (I'd love to repace my file server with one running Raptors, but they don't go big enough...).
*for the purposes of this post I'm ignoring the DHCP server, the laptop, the testbed/victim, and the other... bits.