If you can manage to run a system restore on your computer then you should be able to set the system registry back to a time when the computer was not acting up. This will render most of the spyware inactive and may solve your problems. It would be a good starting point in any event. Then we can proceed from there.
To run system restore:
You can access it through the Start button All Programs > Accessories > System Tools, or by typing rstrui.exe from the Run option