How can i read data from external devices using different ports in VB?

I am developing a software in VB 2010. I want to modify the software a bit, My current software is a simple "Medical Data Management Software" I want that it should also contain a provision where data's from the medical devices can be read and stored in the software, however, I am afraid because the books i am referring does not cover any section related to hardware interaction.

Please help me solving my problem, is there any other book anyone can recommend me, which can help me learning - how can i read data from external devices using different ports in VB 2010.

Thanks & Regards.
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More about read data external devices ports
  1. The first thing you need to let us know is: What type of ports connect to the devices?

    USB, RS-232, something else?
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