Cant install in safe mode

Hello, i can't access system restore. I believe that my computer is highly infected and I can't access system restore. It has been disabled in the registry and when i change it, it changes right back.
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More about cant install safe mode
  1. Boot into safe mode with networking (F8 on startup). Download, install, and update malwarebytes. Do a full system scan.
    http://www.malwarebytes.org/
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Security Safe Mode Computers System Restore Windows XP